Wnt signaling in triple-negative breast cancer
نویسندگان
چکیده
منابع مشابه
Clinicopathological Features of Non-metastatic Triple Negative Breast Cancer
Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based ...
متن کاملTriple-Negative Breast Cancer
Triple-negative breast cancer, so called because it lacks expression of the estrogen receptor, progesterone receptor, and HER2, is often, but not always, a basal-like breast cancer. This review focuses on its origin, molecular and clinical characteristics, and treatment.
متن کاملTriple-Negative Breast Cancer
From the Program in Cancer Genetics, the Research Institute of the McGill University Health Centre, and the Lady Davis Institute of the Jewish General Hospital (W.D.F.); McGill University, Montreal; and the Breast Unit, Royal Marsden Hospital and Institute of Cancer Research (I.E.S.), and the Breakthrough Breast Cancer Research Centre, Institute of Cancer Research (J.S.R.-F.) — both in London. ...
متن کامل[Triple Negative Breast Cancer].
BACKGROUND In the Czech Republic, around 6,500 women get breast cancer each year; out of this number, nearly 1,000 women are triple negative subtype. Triple negative breast cancer is characterized by lack of expression of α-estrogen, progesterone, and HER2 receptors. Vast majority of these cases are low-differentiated carcinomas, majority belonging to the basal-like subgroup defined originally ...
متن کاملTargeting Akt3 signaling in triple-negative breast cancer.
Triple-negative breast cancer (TNBC) is currently the only major breast tumor subtype without effective targeted therapy and, as a consequence, in general has a poor outcome. To identify new therapeutic targets in TNBC, we performed a short hairpin RNA (shRNA) screen for protein kinases commonly amplified and overexpressed in breast cancer. Using this approach, we identified AKT3 as a gene pref...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2017
ISSN: 2157-9024
DOI: 10.1038/oncsis.2017.14